An osmotically controlled oral drug delivery system utilizes osmotic pressure for controlled delivery of active agents. It has gained wider acceptance due to drug release independent of pH and physiological condition of the GIT.Metaproterenolsulfate, a highly soluble drug has been used as a model drug and an attempt has been made to control the release of drug by two different approaches; one using an osmotic agent and a swelling agent. The core tablets were prepared by wet granulation technique and granules before compression were evaluated for micromeritic properties. The core tablets were coated with coating solution containing cellulose acetate, a pore former and a plasticizer to give good film properties. The effect of concentration of osmotic agent and swelling agent on in vitro release was studied and drug release depended on both these factors. The formulation variables like amount of pore former, effect of pH, agitational intensity on in vitro release from optimized formulation was evaluated and it was found that drug release was directly dependent on the amount of pore former in the coating composition. The drug release was independent of pH and agitational intensity of the media. All the formulation released more than 62 % of drug after 12 hrs and drug release from the optimized formulation was found to follow zero order kinetics. The formulation was also found to be stable in terms of hardness, drug content and drug release after 3 months stability study.
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